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KMID : 0363220080460010138
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Korean Journal of Dermatology
2008 Volume.46 No. 1 p.138 ~ p.140
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A Case of Acute Generalized Exanthematous Pustulosis Induced by Hydroxychloroquine
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Choi Joon-Hee
Lee Sook-Kyung
Jeong Yun
Shim Hyun-Soo
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Abstract
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Hydroxychloroquine, an 4-amino-quinoline, has been used widely for the treatment of lupus erythematosus due to its anti-inflammatory and immuno-modulatory activities, as well as for the treatment of malaria. A 37-year-old woman who was suspected as lupus erythematosus and treated with hydroxychloroquine for 3 weeks was seen with exfoliated annular patches and pustules on the trunk, neck, and extremities. Histological examination showed subcorneal and spongiform neutrophilic pustules with perivascular lymphocytes, eosinophils and neutrophils infiltrations. The patient had been treated with systemic steroid and antihistamine. The pustular lesions had improved 2 weeks later without recurrence. The causative drug was confirmed by a positive patch test.
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KEYWORD
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Acute generalized exanthematous pustulosis, Hydroxychloroquine
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